When people think of caffeine, they often think of the coffee beverage or coffee beans, which today are indeed the biggest source of the stimulating chemical in the world. But several popular plants worldwide – around 60 species of them – contain caffeine that have been made into delicious food and drinks from antiquity.
Many of the plants below not only contain caffeine but also are good sources of theophylline and theobromine, two other mild stimulants that scientists believe have some beneficial effects. (Theo means “god” in Latin.)
Coffee was first produced as a drink in Ethiopia, where it still grows in the wild, spreading throughout the east sometime during the fourth century AD. In fact, some of what the coffee consumers drink today is from coffee beans harvested from wild plants growing in the forest. [1, 2]
The amount of (nearly) purely wild coffee is only about 5 percent of Ethiopia’s output, however. Most Ethiopian coffee comes from gardens, plantations and semi-forested areas.
In Asia, caffeine consumption commonly comes in the form of tea. There’s no record of when tea was first used and domesticated, but legend has it that Chinese Emperor Shen Nong was boiling water in his garden when a tea leaf fell into the pot. He tried it and enjoyed its flavor, soon feeling refreshed and invigorated. He also discovered tea’s medicinal properties after this astonishing discovery. 
Tea has been big in India too for many centuries, and there a rather grisly legend says Prince Bodhi-Dharma, founder of Japanese Zen, was preaching Buddhism in China around 520 AD: 
“Towards the end of his meditation efforts he fell asleep. Upon awaking he was so distraught that he cut off his eyelids. A tea plant sprung up from where his bloody eyelids hit the ground to sanctify his sacrifice.”
Here again, historians think people first chewed tea leaves rather than boiling them to make the iconic drink.
When you read the term “natural ingredients” on a can of Coke or Pepsi, it very well may contain flavoring from the kola or cola nut seed.
Kola nut, also known as bissy nut and guru nut, grows in Africa, and Central and South America.
There it is used in foods and beverages to serve to guests and in cultural and social ceremonies and also in traditional medicines.
About the size of a chestnut, the kola nut also comes in the form of an extract with 1.5% to 2.5% caffeine used in food flavouring and cola beverages. 
Kola nuts help relieve fatigue, ease depression, and treat dysentery and migraine headaches.
Cacao, a tropical plant that first grew wild in South American rainforests, is named Theobroma—which is Latin for “Food of the gods.”
Cacao seeds are another natural source of caffeine. It spread north to Mexico, where in the 1400s the Mexican king Montezuma drank up to 50 cups of cocoa per day, according to legend. 
“Cocoa has been a food for humans since as far back as 600 to 200 B.C. when the first hot chocolate drink was made from mashed cocoa seeds. Cocoa is now a major cultivated food crop,” says the Rainforest Alliance. 
The African countries of the Ivory Coast and Ghana are primary exporters of cocoa, but many other countries grow the delicious plant.
People consume cocoa in drinks and as chocolate candy and baked goods. Cocoa butter is also made form cacao seeds.
We have South America to thank for another invigorating, caffeine-containing drink, namely yerba maté.
Also known as maté, terere, and chimarrão, yerba maté leaves and branches are used to make tea, which contains about 70 mg/100 mL of caffeine (compared with coffee at 57 mg/100 mL). 
According to the commercial site Guayaki.com: 
“Yerba maté has the ‘strength of coffee, the health benefits of tea, and the euphoria of chocolate’ all in one beverage. Of the six commonly used stimulants in the world: coffee, tea, kola nut, cocoa and guarana, yerba mate triumphs as the most balanced, delivering both energy and nutrition.”
Yerba maté’s leaves, which grow on trees in the rainforest, contain 24 vitamins and minerals, many antioxidants and 15 amino acids.
A 1964 study by the Pasteur Institute and the Paris Scientific Society said in 1964 that “it is difficult to find a plant in any area of the world equal to maté in nutritional value” and it contains “practically all of the vitamins necessary to sustain life.” 
Maté has some advantages over coffee, including that it is low in bitter tannins, so it can be brewed longer, which allows the nutrients, caffeine, theophylline and theobromine to concentrate more in the liquid. It is less acidic and therefore does not cause upset stomach.
4-Hour Work Week author Tim Ferriss raves about yerba maté tea, especially in boosting cognitive functions:
This is another plant – a vine – that first grew wild in South America. Guaraná (Paullinia cupana), also known as Brazilian cocoa, grows as a shrub or woody vine in Brazil. Because Guaraná seeds have the highest caffeine content (2.5%-5%), it’s been used in Brazilian soft drinks since 1909. 
Guarana seeds, the extract of which is in supplements and energy drinks, contain more than twice as much caffeine as coffee.
“Bombastically named energy drinks such as Full Throttle, Monster, Red Bull and Rockstar all contain the herbal supplement guarana. The compound is also found in over-the-counter weight loss products, and it’s been marketed as an aphrodisiac.” 
If you see guarana on an ingredient list, know that you are in for a big jolt of caffeine when you consume it.
Most of the continents in the World have caffeinated plants. But what about North America?
“North America also has a native caffeinated plant known as cassina, youpon, the Christmas berry tree, or the North American Tea plant, which grows from Virginia, south to Florida, and westward along the Gulf coast into Texas. During the Civil War, when coffee and tea [were] scarce due to blockades, and also after World War I coffee [when] was scarce, cassina became a popular substitute and was the focus of Department of Agriculture projects to cultivate a domestic caffeine source.” 
However, it appears that not too many people drink cassina tea today.
We have good news for lovers of America’s two favorite mood-altering substances, caffeine and marijuana: Caffeine may enhance a pot smoker’s high.
The downside is that caffeine can also increase the chance of becoming addicted to cannabis.
If you often find yourself going to a room in your house only to forget what you’re meant to do, or talking about a movie character you’ve seen so many times but can’t remember the name of, then one thing is going on.
It’s so easy to dismiss these as simple moments of forgetfulness. But if this happens a lot, then it may be your body sending you a signal to do something and beat brain fog.
The writer, Dan Charles, bought a 4-ounce bag of caffeine and said it had as much caffeine as 1,000 tall Starbucks lattes. He said this caffeine was created in coffee beans on a hillside in the tropics. “Slowly and quietly, driven by the energy of sunlight, it formed inside coffee beans hanging on thousands of trees, most likely in Brazil or Vietnam,” Charles wrote.
“Those beans were harvested, loaded on ships bound for the port of Houston, Texas, and ended up at a factory within sight of downtown Houston: Atlantic Coffee Solutions. It’s owned by one of the world’s largest coffee traders, ECOM Agroindustrial Corp., which is based in Switzerland.”